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Monday, July 9, 2007 | Science : Genetics | print version Print | Comments

Document Tinkering with Humans

by William Saletan

Reposted from:
http://www.nytimes.com/2007/07/08/books/review/Saletan.html?ref=science

Three years ago in The Atlantic, the Harvard philosopher Michael Sandel wrote a critique of genetic engineering titled "The Case Against Perfection." Now he has turned it into a book. The title is the same, but the text has changed, and sections have been added. That's what human beings do. We try to improve things.

Sandel worries that this urge to improve can get us into trouble. Steroids, growth hormones, genetic engineering and other enhancements "pose a threat to human dignity" and "diminish our humanity," he argues. That's the way ethicists talk: things are good or bad, human or inhuman. The book's subtitle encapsulates this project: "Ethics in the Age of Genetic Engineering." But genetic engineering is too big for ethics. It changes human nature, and with it, our notions of good and bad. It even changes our notions of perfection. The problem with perfection in the age of self-transformation isn't that it's bad. The problem is that it's incoherent.

Sandel's critique is refreshingly sophisticated. Opponents of eugenic technologies usually complain that they're unsafe, coercive, exploitative, nontherapeutic or unavailable to the poor. Sandel rebuts these objections, pointing out that they're selectively applied and can be technically resolved. His deeper worry is that some kinds of enhancement violate the norms embedded in human practices. Baseball, for example, is supposed to develop and celebrate an array of talents. Steroids warp the game. Parents are supposed to cultivate children through unconditional as well as conditional love. Selecting a baby's sex betrays that relationship.

How do we know these norms exist? Because when they're violated, something in us rebels. When parents choose their children's sex, we recoil. When baseball players use steroids, we frown. We, the audience, embody and express the norm.

But audiences, too, can change. Look what happened to Broadway musicals. Thanks to sound amplification, "audiences inevitably grew less alert, more passive," Sandel observes. Musicals became less verbally clever, but we no longer cared. We were "rehabituated." Sandel laments this, but it's not clear why. If everything has changed — the practice, the audience, the norms — what basis for complaint remains?

When norms change, you can always find old fogeys who grouse that things aren't the way they used to be. In the case of football, Sandel finds a retired N.F.L. player to support his contention that today's bulked-up linemen are "degrading to the game" and to players' "dignity." But eventually, the old fogeys die out, and the new norms solidify. Sandel recalls a scene from the movie "Chariots of Fire," set in the years before the 1924 Olympics, in which a runner was rebuked for using a coach. Supposedly, this violated the spirit of amateur competition. Today, nobody blinks at running coaches. The standpoint from which people used to find them unseemly is gone.

To defend the old ways against the new, Sandel needs something deeper: a common foundation for the various norms in sports, arts and parenting. He thinks he has found it in the idea of giftedness. To some degree, being a good parent, athlete or performer is about accepting and cherishing the raw material you've been given to work with. Strengthen your body, but respect it. Challenge your child, but love her. Celebrate nature. Don't try to control everything.

Why should we accept our lot as a gift? Because the loss of such reverence would change our moral landscape. "If genetic engineering enabled us to override the results of the genetic lottery," Sandel worries, we might lose "our capacity to see ourselves as sharing a common fate." Moreover, "if bioengineering made the myth of the 'self-made man' come true, it would be difficult to view our talents as gifts for which we are indebted rather than achievements for which we are responsible."

Well, yes. In such a world, it would be hard to see ourselves as slaves to the genetic lottery or to a common fate because that perception would no longer be true. But why defend a perception against a truth? It's a particularly awkward posture for a philosopher like Sandel, who infers norms and virtues from the way people live. Once gene therapy becomes routine, the case against genetic engineering will sound as quaint as the case against running coaches.

If the genetic lottery were better than the self-made man, we might prefer the old truth to the new one. But Sandel's egalitarian fatalism already feels a bit 20th-century. The older half of me shares his dismay that some parents feel blamed for carrying babies with Down syndrome to term. But my younger half cringes at his flight from the "burden of decision" and "explosion of responsibility" that come with our expanding genetic power. Given a choice between a world of fate and blamelessness and a world of freedom and responsibility, I'll take the latter. Such a world may be, as Sandel says, too daunting for the humans of today. But not for the humans of tomorrow.

Sandel thinks this vision of freedom is flawed. Part of freedom, he argues, "consists in a persisting negotiation with the given." To abolish the given by re-engineering not only our world but also ourselves would "leave us with nothing to affirm or behold outside our own will." This is a profound insight. But it's not fatal to freedom. It's fatal to perfection.

In a world without givens, a world controlled by bioengineering, we would dictate our nature as well as our practices and norms. We would gain unprecedented power to redefine the good. In so doing, we would strip perfection of its independence. Its meaning would evolve as our nature and our ideals evolved. The more successfully we engineered I.Q. and muscle-to-fat ratio, the more central these measures would become to our idea of perfection. We already see this phenomenon in our shift of educational emphasis from character to academic testing. We might create a world of perfect SATs, E.R.A.'s and C.E.O.'s. But it would never be a perfect world, because the point of perfection is that its definition doesn't bend to our will.

This is the real problem with self-engineering. It seizes control of humanity so radically that humanity can no longer judge it. We can't be certain it's diminishing us. But we can't be certain it's perfecting us, either. Sandel got it half right, which ain't bad. Nobody's perfect.

William Saletan writes Slate's "Human Nature" column and is the author of "Bearing Right: How Conservatives Won the Abortion War."

Comments 1 - 22 of 22 |

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1. Comment #54922 by gordon on July 9, 2007 at 10:27 am

 avatarWhat a load of rubbish! Stop thinking, stop creating, stop researching, stop inquiring, stop progressing, stop moving on the edge, we might fall off, stop living!

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2. Comment #54936 by konquererz on July 9, 2007 at 11:27 am

 avatarIn the end, nothing will help humanity more that discovery and invention. Even things that are bad for us at first, we can ultimately turn into a good. Its the evolution of humanity, even cultural evolution, that has shown time and again that human advancement is a good thing. But time and time again someone speaks out against progress and advancement that something bad will happen. No it won't. The world will continue on like it always has, finding ways to adapt to the world around it. What it really boils down to is fear of change. The idea that change of this magnitude will be bad simply because its change. The fact it that history paints a different picture. change drives civilizations to be better and to adapt to live better.

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3. Comment #55022 by Big T on July 9, 2007 at 6:09 pm

I used to be creeped-out by the notion of parents choosing what attributes their children will have, and I still have some doubts about it. However, tinkering with the human genome to produce more people with an I.Q. like E.O. Wilson, and fewer people with an I.Q. like the late Jerry Falwell is probably the best hope for humanity we have. Anyway, it is inevitable.

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4. Comment #55069 by roach on July 10, 2007 at 12:21 am

Gordon: Are you talking about the article with your post? Or are you talking about Sandel? Saletan appears to be very open to the idea of human genetic engineering.

Anyway, just engineer everyone to be more intelligent and compassionate. That should save us some trouble. But even that pleasant scenario makes me cringe. It really does feel like that would be cheating.

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5. Comment #55076 by gordon on July 10, 2007 at 12:55 am

 avatarRoach,

Do we not already have engineering? Will we not engineer out disease if the opportunity arrives. In two hundred years this discusion will be academic? The more we move forward in genetics will make this possible. There will not be a line in the sand we should not cross. There never is.

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6. Comment #55143 by nancy2001 on July 10, 2007 at 5:31 am

Both the book and the last two paragraphs of the article are ridiculous. Every day each one of us cheats "Mother Nature" in a thousand ways. Why not destroy your eyeglasses so you can "celebrate" myopia and astigmatism.

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7. Comment #55157 by Diplo on July 10, 2007 at 6:16 am

 avatarCouldn't it be argued that the next step in natural evolution would be for organisms to evolve the ability to alter their genome for the better?

The revelations and discoveries we make through science tend to be ethically neutral. It's up to us as human beings to work out the moral implications of technology and science. We should be careful, but not fearful.

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8. Comment #55280 by roach on July 10, 2007 at 12:48 pm

Gordon,

I'm just going to assume you were talking about Sandel.

Anyway, of course we have engineering. And I'm quite happy about it. I reap the benefits of science and engineering every second of my life. And yes I would be in favor of eliminating disease on the genome level. If that is what the article was about I would have made a much different post. But we are discussing the very real possibility of designing people. That is, making them taller, smarter, longer lived, etc. through genetic alterations. One big problem to me is that humans, being the evolved creatures they are, are inherently self-interested. And I think our ethics have not caught up to our amazing technological abilities. As such, it seems to me that a small percentage of the human population would gain the most benefit from these advances in genetics. I think there is a very real chance that these advances could actually widen the divisions we see in the world.

I would agree that there are no lines in the sand waiting for us. It is up to us to draw the lines.

Should we draw a line? I don't know.

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9. Comment #55291 by Bonzai on July 10, 2007 at 1:17 pm

Couldn't it be argued that the next step in natural evolution would be for organisms to evolve the ability to alter their genome for the better?


That is a good question. But "better" is a loaded word. Why are certain traits valued more than the others? Why are certain characteristics deemed more,--or less,--desirable? Moreover, "better" for whom? These are often value judgments for which science doesn't have answers. Social norms on these matters are frequently expressions of unconscious prejudices and the preferences of powerful groups within the society.

Are we ethically mature enough as a society to make those judgments? Who will be making those judgments on the society's behalf? Who will control this technology?

I am sure authoritarian types would be interested in genetically designing obedient, docile people; after all don't we always hear parents and teachers complaining about young people being out of control? It is a boon that such a race of sheepish people would be ideal to serve in the military or do menial jobs.

Many people would be delighted that there is finally the possibility of eliminating the "gay gene" once and for all. It would be a gold mine for scientists who advertise that they have a surefire "cure" for homosexuality.

Sorry to rain on your parade. I don't think we as a society can handle the responsibility of designing humans. It is not difficult to see how such technology is liable to being perverted and hijacked by greed, ignorance and other questionable agendas. Eugenics is not really that remote a memory. To have an idea of what may go wrong in a more mundane setting you only have to take a look at legal drug abuse by the medical- pharmaceutical industry and multiply the effects by a factor of 1000.

The revelations and discoveries we make through science tend to be ethically neutral. It's up to us as human beings to work out the moral implications of technology and science. We should be careful, but not fearful.


Technology may be neutral but its deployment is not. It is made by people who have power often at the expense of those who don't. A new, labour saving invention can mean more leisure time , higher income for all, or it can mean vast profits for some and mass unemployment for others.

Power is not neutral. We cannot seriously talk about the pros and cons of designing humans without taking this into account,--along with other considerations. Technology doesn't exist in a social vacuum.


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10. Comment #55304 by gordon on July 10, 2007 at 2:04 pm

 avatarRoach,

I hail from what was a very poor mining village in the North of England. Looking back, most of the northern mining and industrial towns and villages were culturally deprived and deliberately so. Workers were shipped in to a new mine (mill, steelworks, take your pick) to create a workforce and to service the mine, nothing else. It was so bleak. Whether they were financially rewarded or not and they certainly weren't at first, life was hard and cultural awareness was not encouraged, nor was longevity after a productive spell.. That seems to be the case for many third world villages now. They cannot have what we expect as we cannot all be on top of the pile and we don't want to give it them, at the possible cost of us not having it (whatever 'it' is). Obviously wealth and comfort. Imagine if tomorrow someone discovered a method to enable humans to extend their lives two or three hundred years and it was feasible to use the drug/solution/magic potion but obviously difficult to make and expensive. Who would get it? Presumably it would go to those that could pay, like many health care solutions that exist now. It wouldn't be shared so should those who are left out accept this? Health divisions and depravations are accepted by enlarge now so why would this be any different? Are the underprivileged more connected now or does the rise in communications and technology push the have-nots even lower? Most drug companies are researching and manufacturing drugs for the top ten percent of humanity. Simple cures for the most devastating diseases are already available but are not distributed so it's hard to believe a magic pill will make much difference. Not many rich people die of AIDS now, only the poor.

The gap between the super rich and the poor is already astronomical and getting wider. This is already happening. We are crossing the line on a daily basis. If you are on the wrong side of the divide and have the intelligence to see it, what are you going to do? Fight for your rights or try to be accepted in the higher group? As technology escalates, only a few will understand and begin to manipulate the changes. By the time an ethical decision is made (by who?) it is already moot. The super rich will benefit faster under our current systems. The question is not what we can do about it but who will do anything about it .

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11. Comment #55311 by Bonzai on July 10, 2007 at 2:30 pm

Gordon wrote:

Health divisions and depravations are accepted by enlarge now so why would this be any different?


Well it should not be accepted and indeed many people don't. That's why many people continue to fight for a more just, more equitable world.

You have just eloquently described why we should indeed draw a line in the sand against "designer babies", at least in the present. Hitler's concept of a master race is repugnant to all decent people. The notion of a master race, determined by wallet size instead of skin colour, is just as reprehensible.

Incidentally, why do you assume genetic tinkering will only be used to extend lives and eliminate diseases? Gene therapy is not quite the same concept as designing humans. Gene therapy is specific and limited in scope. The possibility of designing humans opens up entirely new opportunities and techniques for social control undreamt of even in Huxley's brave new world.

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12. Comment #55345 by roach on July 10, 2007 at 5:31 pm

Many thanks to Bonzai. You wrote almost exactly what I was thinking while reading Gordon's post. I say almost because your words are much clearer than the thoughts that popped into my head.

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13. Comment #55403 by gordon on July 11, 2007 at 3:00 am

 avatarBonzai,

'Well it should not be accepted and indeed many people don't. That's why many people continue to fight for a more just, more equitable world.'

Where are these people? Two thirds of the planet are simply trying to put food on the table. The Religious leaders are trying to control the people putting food on the table and milk them for cash. Most science (and scientists) and science establishments, outside of a few universities are in hoc to large corporations. Ninety percent of politicians in the developing world are corrupt beyond imagination. Many politicians in the developed world outside of accountable democracies are similarly corrupt. Many politicians in the developed democracies are in the grip of the faith 'interminable growth' no matter what the cost in terms of the planet or social cohesion even if they aren't corrupt. To whom are we looking for leadership? Al Gore? I don't think so, he and his boss failed in power once and he shouldn't get a second chance. Fox news? Religious leaders, charlatans all. Communism? Failed dogma and now turned to Gansta Capitalism.

There is always a difference between the pursuit of science for knowledge and the use of science. Whilst science has been put to great use in feeding and nurturing most people, it also regularly abused. For instance, here in the UK there is a great animosity to genetic tampering with food. I myself have great misgivings. It's not that I am afraid of the science, the 'Frankenstein food' aspect if you like; it's the people using the technology that worry me. If a crop is manufactured to improve value, taste and resistance to chemicals etc for the purpose of making food cheaper and increase crop yields, improves the soil and bio-diversity, then it obviously has to be a good idea. Similarly, creating rice that gives much needed vitamins to third world residents in the absence of anything similar in their diet is a no-brainer. Unfortunately it does seem that many of the advances are purely to increase reliability on fertilisers and pesticides produced by the manufacturers of the genetically altered seed and to make buyers have to return year after year to the same manufacturers for a return crop. These 'Zombie' crops are infertile, so, whereas third world farmers would always keep a portion of the harvest for next years sowing, now they have to either buy again from the suppliers, or, they have to buy a chemical to activate the seed. Profit first, ethics second.

We live in a society which promotes greed. One is measured by wealth. Celebrity culture is all and holds others in thrall. Our pop stars trail around the sub-continent to pick up cute black babies to salve their conscience and decorate their houses. Our artists have become media hogs and retail barons. Their work is about themselves, endlessly promoted. When they are offered designer babies they will be thrilled at the prospect and jump at the chance. This will perpetuate the advantages of wealth. Some writers buck the trend, as do some politicians, mainly; it has to be said, from the western parts of Europe. Maybe true atheists like Henri Bergsen (see other threads) who define morality as a faith will grasp the opportunity for eternal existence knowing this is all we have?

My proposition is that there will be no line drawn. Unless we close the distance between rich and poor before this happens, the gap will get wider exponentially. Maybe climate change will thin the ranks and remove some of the problems; this seems to be the Bush administration's view.

There is discussion but it is mainly underground. Ninety nine percent of the world media is privately owned by the people who would want to perpetuate wealth division. There are a few media outlets who list toward intelligent debate (and yes I would list the BBC in this sphere), but most are dumbed down to serve as a balm.

So I ask again, where is the movement toward a just and fairer world? As it has never existed, what makes you think we can achieve it in the future?

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14. Comment #55410 by Rtambree on July 11, 2007 at 3:30 am

Gordon & Bonzai,

>Unless we close the distance between rich and poor before this happens, the gap will get wider exponentially

The way that we look back today at slavery, racism, and genocide with disgust, is how I think future generations will look back at our time and ask "How can humans living in 2007 think it was right that some people are so obscenely wealthy while millions die from preventable diseases".

During the time of slavery before 200 years ago, it was perceived as perfectly normal, the natural social order, and justified by most intellectuals of the day.

Just like today, the massive gap between rich and poor is thought of as normal and justified by the mainstream press and many conservative and liberal intellectuals.

The crossover of the chromosones during meosis creates the initial inequality, but capitalism and inheritance amplifies whatever initial starting conditions there are between genomes. We share over 99% of our DNA, and yet some have billions and many have zilch.

Just like we have a sugar & fat preference from the African savannah that's now dysfunctional, we have a status-craving and wealth accumulation that's completely incompatible with 21st century society. Environmental concerns only excerbate this.

Every budget, tax rates for the rich come down, and each year paintings and real estate reach new record prices. Last week the Independent ran ads for 24-carat gold bins. Handbags in Mayfair sell for thousands of pounds. Entire areas of Chelsea, Kensington, etc are full of luxury saloons and sports cars. All the evidence suggests that there's no long term satisfaction to accumulating lots of shiny stuff, and yet we do it as we don't know what else do to. Prisoners of our genes.

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15. Comment #55417 by pewkatchoo on July 11, 2007 at 3:52 am

 avatarTo argue that a child is less loved because its parents chose its gender is ridiculous in the extreme. Some care is of course needed with genetic engineering, but that could be covered by sensible guidelines instead of seeing it as the big boogeyman. As for stem cell research, just what is wrong with the US? Does Bush even know what a stem cell is?

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16. Comment #55418 by pewkatchoo on July 11, 2007 at 3:56 am

 avatarI loved Iain M Banks Culture society in his SF series. I thought that was a decent direction and showed what might be possible in the future with self-controlled genetic engineering. Long productive lives without disease, changing gender when you felt like it, no money driven economy. Excellent stuff.

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17. Comment #55422 by gordon on July 11, 2007 at 4:08 am

 avatarRtambree

"The way that we look back today at slavery, racism, and genocide with disgust, is how I think future generations will look back at our time and ask "How can humans living in 2007 think it was right that some people are so obscenely wealthy while millions die from preventable diseases".

This is because our definition of morality changes. However, there are many who would like to return to the days of slavery albeit better dressed and not as smelly. The few thinkers with what could loosely be termed and altruistic inclination or a bias toward compassion for the most part avoid power. This makes them weak. I read Richard Dawkins say that trying to get free thinkers and atheists together is like trying to herd cats. Capitalism is our religion now. Even here in the UK, Gordon Brown has to pander to the rich whilst using underhand and stealth taxes to redistribute wealth, quietly, like a drug dealer down a dark alley. Whereas once our artists and writers set the pace and agenda for reform and highlighted our humanism, nowadays they are in the grip of the system, selling novelty items for high prices like Damien Hirst's diamond encrusted skull. Art galleries have become shopping malls.

I have a regard for Bill Gates. Just think of the power he could buy but he has elected to give much of his money away without seeking political office. I don't see many others doing likewise and I don't see a group giving direction or definition of what could be achieved.

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18. Comment #55713 by logical on July 12, 2007 at 3:55 am

 avatar"(A) world of fate and blamelessness"
did never exist. Born unwanted´s were always called bastards and brutalized, and there is the thing missing: Human rights begin with the right to decide to have a child or not.
As this is still not recognized - as the reviewer should know!!! - the minor decisions about genes can be made into something big, which they are not.
And, Big T, with the I.Q. of E.O. Wilson you may be right, but the aggression and the delusions of individuals like the late Jerry Falwell is better explained by imprint - a horrible childhood experience of being born unwanted.
On German tv there was an interview with the cardinal of Cologne, Joachim Meisner, where he next to perfectly admitted that he wanted to make people repeat his childhood experience - this was when the books by Alice Miller were bestsellers.

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19. Comment #55718 by Mat on July 12, 2007 at 4:09 am

Maybe this is the next Darwinian speciation for humanity. Homo Sapiens Lucratus will take over from Homo Sapiens Sapiens. But for those of us without the lucre - look what happened to the Neanderthals that co-existed with modern humans...

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20. Comment #55890 by roach on July 12, 2007 at 7:01 pm

Gordon,

Although I don't agree with some of what you say i.e. capitalism is our religion now, I do agree with much. But you are only giving me more reasons to be against genetic "tinkering". Perhaps if we could make people more egalitarian and compassionate I would take a different view. But I would still have to think about it and discuss it with many people.

I'm of the opinion that we must outgrow our darwinian past before we start designing humans.

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21. Comment #55934 by gordon on July 13, 2007 at 1:08 am

 avatarRoach,

I agree we (as a species) should outgrow our Darwinian past; it's just that I do not see it happening in any meaningful numbers. The people in control of the planet are Darwinian driven. Great thinkers can, at times, step aside from this position but they have no control (as can not so great thinkers). The chaps (and they are mostly men) who control the planet are by enlarge either traders ruthless in their chosen field or Dictators as warrior kings, enslaving their people. Most scientists have their head down, busily engaged in their work but have little say in the resulting use. Others use science as another useful technology to favour their lifestyle. I cannot, as a group see us developing as quickly as the technology.

On the plus side, Gordon Brown has stopped the development of Super Casinos here in the UK, a tax on the poor if ever there was one. So you see, there is a glimmer of hope.

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22. Comment #107687 by the_ultimate_samurai on January 5, 2008 at 1:46 am

i would say the idea of genetically engineering your child is dangerous, while i am in favour of the creation of bio-machines to serve us, i am not in favour of the idea of editing humans, one thing is just the child. if a parent selects for a child what they want their child to have, athleticism, iq, etc, they are basically mapping out this childs destiny, and i think that is too controling.
some things, yes, if you can increase a childs IQ...you should...but of course in a society where realy your iq is you livelyhood (lets face it manipulation takes some form of intelegence, so even the jerry fallwells of the world have the intelegence, they just arent academic) this is kinda like the issue of steroids. and it is a survival of the fittest situation (social evolution)
follows like this:
one parrent genetically engineers their child to be athletic and intelegent, smarter than einstein and more disposed to be physically fit (metabolism mostly, less disorders too. whether they work out is up to them) this child of course becomes unbelievably successfull (in something im sure) including in issues of romance (kinda hit or miss, but being athletic and smart gives you and advantage...but he could be a total jerk and not get any...like i said, hit or miss.)
this child being successful makes more parrents want the same for their child.
and similar results.
now no one is forcing everyone to engineer their child. just like no one is forcing everyone in sports to take sterroids. but those who dont are less competitive than those who do. there is a selective pressure. and when you reach a critical mass it becomes such that those who arent engineered are just about second class citizens to those are. if you do engineer children who break all known benchmarks, what of the average man, what of the child who wasnt engineered because their parents wished them to be born natural. they have the ability to chose...but that is only superficial, in reality...they have very little choice. if they want the best for their child, they would have to.

and then, since these children must reproduce, what of their offspring, can we acount for untold mutations down the line. in that manner it kinda goes to chaos theory.

bio-machines that cant breed and exist to service us is one thing, but changing us, at the expense of the un-changed...i dont support that.


now if you can genetically engineer a smart virus (a retro-virus which changes the dna of everyone it encounters to make them smarter, or the next generation smarter) and release it as an airborne virus...that would be nice...(unfortunately same issue arises, by nature such a virus would have to reproduce, and by nature of resproduction it would be subject to change...though a non-deleterious gene designed to allow them to be self destructed could be engineered, but thats getting WAAAY ahead of myself, which i do....a lot....)

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