By CARL ZIMMER - NY TIMES
Added: Thu, 31 Dec 2009 00:00:00 UTC

http://www.nytimes.com/2010/01/01/science/01devil.html

The Tasmanian devil, the spaniel-size marsupial found on the Australian island of Tasmania, has been hurtling toward extinction in recent years, the victim of a bizarre and mysterious facial cancer that spreads like a plague.

Now Australian scientists say they have discovered how the cancer originated. The finding, being reported Friday in the journal Science, sheds light on how cancer cells can sometimes liberate themselves from the hosts where they first emerged. On a more practical level, it also opens the door to devising vaccines that could save the Tasmanian devils.

“It’s a great paper,” said Katherine Belov, a geneticist at the University of Sydney who was not involved in the study. “Previously, we were stumbling in the dark.”

The cancer, devil’s facial tumor disease, is transmitted when the animals bite each other’s faces during fights. It grows rapidly, choking off the animal’s mouth and spreading to other organs. The disease has wiped out 60 percent of all Tasmanian devils since it was first observed in 1996, and some ecologists predict that it could obliterate the entire wild population within 35 years.

When the tumor disease was discovered, many assumed it was caused by a rapidly spreading virus. Viruses cause 15 percent of all cancers in humans, and are also widespread in animals.

But subsequent studies failed to turn up a virus. Instead, Anne-Maree Pearse and Kate Swift of the Department of Primary Industries, Water and Environment in Tasmania, discovered something strange about the tumor cells. The chromosomes looked less like those in the animal’s normal cells and more like those in the tumors growing in other Tasmanian devils.

In 2007, Dr. Belov and her colleagues compared snippets of DNA from 26 sick and healthy Tasmanian devils with DNA from the tumors. They found that cancer cells from different animals shared distinctive genetic markers not found in the animals themselves.
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http://www.nytimes.com/2010/01/01/science/01devil.html

TAGGED: BIOLOGY, EVOLUTION, MEDICINE