By SARAH BOSELEY - THE GUARDIAN
Added: Wed, 19 Oct 2011 15:32:50 UTC

The first-ever widescale trial of a malaria vaccine has produced promising results, say researchers, raising hopes of an imminent breakthrough in the fight against the mosquito-borne tropical disease. Photograph: Pa

Millions of children's lives could be saved by a new vaccine shown to halve the risk of malaria in the first large-scale trials across seven African countries.

The long-awaited results of the largest-ever malaria vaccine study, involving 15,460 babies and small children, show that it could massively reduce the impact of the much-feared killer disease. Malaria takes nearly 800,000 lives a year – mostly children under five. It damages many more.

The vaccine has been in development for two decades – the brainchild of scientists at the UK drug company GlaxoSmithKline, which has promised to sell it at no more than a fraction over cost-price, with the excess being ploughed back into further tropical disease research.

"This data brings us to the cusp of having the world's first malaria vaccine, which has the potential to significantly improve the outlook for children living in malaria endemic regions across Africa," said GSK's chief executive, Andrew Witty.

"The addition of a malaria vaccine to existing control interventions, such as bed nets and insecticide spraying, could potentially help prevent millions of cases of this debilitating disease. It could also reduce the burden on hospital services, freeing up much-needed beds to treat other patients who often live in remote villages, with little or no access to healthcare."

Witty told the Guardian he was thrilled for the scientists, who were thought by many of their peers to be attempting the impossible when they started work on a vaccine 25 years ago. "When the team was first shown the data, quite a number of them broke down in tears," he said. "It was the emotion of what they had achieved – the first vaccine against a parasitic form of infection. They were overwhelmed. It says something about the amount of heart that has gone into this project."

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TAGGED: MEDICINE, SCIENCE