Our knowledge of RNA interference — popularly known as RNAi — has expanded dramatically in the short time since its discovery. Several types of small silencing RNAs have now been discovered, including small interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs).
Small RNAs are involved in regulating gene expression in many ways, and RNAi is being harnessed by scientists for laboratory research and for the development of new therapies for disease.
This animation introduces the principles of RNAi involving siRNAs and miRNAs. We take you on an audio-visual journey through the steps of gene expression and give an up-to-date view of how RNAi can silence specific mRNAs in the cytoplasm.
Extra information about RNAi is provided in an accompanying slideshow.