No adverse effects in volunteers following Phase I clinical trial of Sumagen AIDS vaccine

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Sumagen Canada Inc and Western University announced today that the Phase I Clinical Trial (SAV CT 01) of the first and only preventative HIV vaccine based on a genetically modified killed whole virus (SAV001-H) has been successfully completed with no adverse effects in all patients. Antibody production was also boosted after vaccination. 


Developed by Dr. Chil-Yong Kang and his team at Western's Schulich School of Medicine & Dentistry, with the support of Sumagen Canada, the vaccine (SAV001-H) holds tremendous promise for success in the final phases of clinical testing now that the first hurdle has been accomplished. It is the only HIV vaccine developed in Canada currently in clinical trial, and one of only a few in the world. This vaccine is the first genetically modified killed whole virus vaccine (SAV001-H) in human clinical trial to evaluate its safety, tolerability and immune responses. The human clinical trial was initiated in March 2012 and completed in August 2013. This trial was a randomized, observer-blinded, placebo-controlled study of killed whole HIV-1 vaccine (SAV001-H) following intramuscular (IM) administration. HIV-infected, asymptomatic men and women, 18 to 50 years of age, have been enrolled in this study and randomized into two treatment groups to administer killed whole HIV-1 vaccine (SAV001-H) or placebo. 

The adverse effects after vaccination were recorded on a volunteer diary card by the volunteers seven days after vaccination. Thereafter, the volunteers visited the test sites on Weeks 4, 6, 12, 18, 26 and 52 after vaccination and were analyzed for hematology, clinical chemistry, urinalysis and physical examination by principal investigators. No serious adverse event was observed in any volunteer vaccinees throughout the observation periods.

Written By: Western University
continue to source article at communications.uwo.ca

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  1. Let’s say the vaccine offers 90% immunity. It might end up making matters worse. Some people would trust the vaccine where previously they trusted safe sex practices.

    In Africa, the problem is out of control because there are so many people with HIV that unprotected sex leads immediately to infection. There are too many sources of infection. If you can get that number down via early detection and treatment or a vaccine, then unprotected sex becomes much less dangerous.

    When we use the vaccine, we have to strongly emphasise this is a backup, not the primary protection.

    • In reply to #2 by Roedy:

      In Africa, the problem is out of control because there are so many people with HIV that unprotected sex leads immediately to infection. There are too many sources of infection. If you can get that number down via early detection and treatment or a vaccine, then unprotected sex becomes much less dangerous.

      There is currently another form of “AIDS protection” campaign going on in Africa: systematic mass circumcision of young men between 15 and 28. There seems to be this belief that being circumcised makes a man less prone to propagate and/or contract HIV… Is there any scientific basis to this? I am kind of skeptical myself…

      • In reply to #3 by NearlyNakedApe:

        In reply to #2 by Roedy:

        In Africa, the problem is out of control because there are so many people with HIV that unprotected sex leads immediately to infection. There are too many sources of infection. If you can get that number down via early detection and treatment or a vaccine, then unprotected…

        I think “less likely ‘ is not ‘ absolute protection.

      • In reply to #3 by NearlyNakedApe:

        In reply to #2 by Roedy:

        In Africa, the problem is out of control because there are so many people with HIV that unprotected sex leads immediately to infection. There are too many sources of infection. If you can get that number down via early detection and treatment or a vaccine, then unprotected…

        I believe so. I argue circumcision is a barbaric, genital mutilation, first practiced to enhance the practice rape for conquering armies*, and that this is done to babies make me sympathize with Blood Libel. In my study of this, I do concede it reduces HIV on the continent of Africa, where the virus-model is denied and babies are raped out of the myth that virgins can cure HIV. In the pits of hell, it can save a few lives.

        This was also observed in WWI with American troops. Being the only troops to be given abstinence training instead of condoms, they were a great epidemiology study. Uncut men were more likely to contract bacterial infections, as the foreskin incubates the organisms, which evolved to thrive in that environment. In the case of HIV, the virus is very delicate and must avoid oxygen. Generally speaking, infection is much less likely from a woman to a man, and foreskin increases likelihood of infection. I’ve also seen stats related country to country to support the argument, but I only feel like citing one source right now.

        *The Torah

      • SA, if I am not mistaken has the largest number of HIV positive people in the world.This problem is exacerbated by the shocking levels of ignorance and cruelty in the country.From the cringe making, ignoramus president Zuma who had a shower after sex with a hiv positive woman , hoping to reduce his chance of getting AIDS that way, to the men who rape virgins and BABIES to cure themselves.Then we have the nitwits who get free antiretrovirals but neglect to take them. Where this will all end I don’t know….In reply to #3 by NearlyNakedApe:

        In reply to #2 by Roedy:

        In Africa, the problem is out of control because there are so many people with HIV that unprotected sex leads immediately to infection. There are too many sources of infection. If you can get that number down via early detection and treatment or a vaccine, then unprotected…

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