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Lab-grown organoids are more stressed-out than actual brain cells
Brainlike clumps of cells don’t behave like cells taken from tissue

https://www.sciencenews.org/article/lab-grown-organoids-more-stressed-out-than-actual-brain-cells

… Abnormal (grown in test tube) human organoid cells became a little bit more normal when implanted into a more hospitable environment — mice’s brains. After growing for several weeks in a more normal environment with a blood supply, the organoid cells seemed less stressed. And the cells no longer seemed as confused about their identities.

The researchers don’t know exactly what causes the abnormalities in the organoid cells. It might have to do with the nourishing liquid that surrounds the blobs, or even differences in the mechanical forces that press against them. …

Interesting stuff here.

Seems to me another example of that fundamental lesson that we cannot understand an organism without also understanding it’s environment.