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That seems a good point, Widdershins.

I would just chip in that:

If you throw a rat (that has had part of its own brain ablated, so that the rat has become almost catatonic) into a tub of water, it will suddenly become quite frantically active, trying no to drown).  So maybe the “organoids” are a bit like that, in that they exhibit the stress reactions when they are in an unsuitable environment.