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I suppose you are getting at the determined nature of the universe.  Whatever we do, occurs by virtue of natural laws.  Yes.

Our values/morals are determined according to natural laws.  If we act in discordance with our values/morals, we are guilty.  (In compatibilist free will, one is not guilty if they act in accordance with their belief systems. Also if they are forced to act in discordance with their value system, they would not be guilty.)

That is one level of guilt v. innocence.  Another is the legal/& social system in which we live.  If we break a law/more, even if doing so was consistent with our own values/morals/beliefs – we are considered by society (if it is proven) to be guilty.

We humans create laws, morals, values, mores, ethical considerations, guidelines, etc.  We created the G/gods and religions that developed their particular rules, commandments, morals, etc.   All of that morality stuff came from the mind of humans.  ALL OF IT.

Did Mark Twain say something like, “Humans are the only creature that knows right and wrong, and chooses to do wrong anyway.”?